Calcium diascorbate
Calcium diascorbate
CAS: 5743-27-1
Molecular Formula: C12H14CaO12
Calcium diascorbate - Names and Identifiers
Calcium diascorbate - Physico-chemical Properties
| Molecular Formula | C12H14CaO12 |
| Molar Mass | 390.31 |
| Physical and Chemical Properties | Chemical white or slightly yellow crystalline powder, odorless. Soluble in water, slightly soluble in ethanol, insoluble in ether. ADI does not make special regulations (FAO/WHO,1994). |
| Use | Used as an antioxidant, China stipulates that it can be used in meat products and soups, with a maximum use of 1.0 g/kg (based on ascorbic acid in oil); For instant noodles and crisp cakes, the maximum use is 0.2 g/kg; It can also be used as a nutritional fortifier. |
Calcium diascorbate - Uses and synthesis methods
Introduction
Calcium vitamin C is a neutral ascorbate that has no irritation to the stomach. While supplementing vitamin C, it can also provide about 10% of very easily absorbed calcium. Vitamin C calcium sets anti-oxidation, anti-virus, anti-toxin, anti-allergy, enhance immunity, and is an important factor in the synthesis of the most important supporting tissue collagen in the body, as well as the controversial anti-cancer effect, which is important for growth and development, Maintaining health and fighting diseases are increasingly gaining wider recognition.
physiological functions and effects
Vitamin C calcium has the same pharmacological effects of vitamin C and calcium. It can be used to treat vitamin C and prevent and treat calcium deficiency. After vitamin C is made into calcium salt, it is easier to be absorbed by the human body and its stability is enhanced. Vitamin C calcium has been widely used in medicine and food industry abroad. In the food industry, vitamin C calcium can be used as an antioxidant, fortifier and additive for food.
indications
this product is a vitamin c supplement.
1. treat vitamin c deficiency.
2. Provide the high content of vitamin C required by the human immune system to reduce the duration and frequency of viral infections.
3. Meet the additional demand for vitamin C for people with digestive and absorption disorders during pregnancy, lactation, surgery, antibiotic treatment, and frequent smokers.
pharmacological action
Vitamin C calcium is involved in amino acid metabolism, neurotransmitter, collagen and interstitial synthesis. Supplementing appropriate amount of vitamin C and calcium can promote the body's nutritional metabolism and energy production, enhance immune function, improve vascular adaptability, improve the elasticity and tension of skin, blood vessels and other tissues, and improve the body's ability to respond to stress (such as infection, etc.). In vivo, ascorbic acid and dehydroascorbic acid form a reversible redox system, which plays an important role in biological oxidation and reduction processes and cell respiration.
Pharmacokinetics
After oral administration, it is quickly absorbed by the gastrointestinal tract and decomposed into vitamin C and calcium ions. Vitamin C is distributed in various tissues and organs in the body, with the highest concentration in gland tissues and the lowest in muscle fat; the concentration in white blood cells and platelets is higher than that in red blood cells and plasma. Part of vitamin C is metabolized in the body into oxalic acid and carbon dioxide, and part is excreted in urine in reduced or dehydrogenated form. If the plasma concentration of vitamin C exceeds the renal threshold (about 1.4mg%), and then continue administration, most of it will be excreted in urine. If the plasma content is less than 1.4mg%, the vitamin C taken is taken up by tissue cells and rarely appears in urine.
production method
1. use vitamin c and calcium carbonate as raw materials to react without adding nitrogen: add 44gVC and a certain amount of water into a three-mouth bottle equipped with an electric stirrer, control the reaction temperature with a water bath, and slowly add a certain amount of calcium carbonate under uniform stirring to keep the liquid level covered by CO2. After the reaction is complete, the filtrate is filtered, the filtrate is transferred to a three-mouth bottle, a large amount of methanol is added at room temperature, and the crystallization is slowly alcoholized. After the addition, the temperature is continuously cooled, the filter is pumped, the methanol is washed, and the vacuum is dried to obtain the finished vitamin C calcium. The optimum technological conditions are as follows: water addition amount 1 mL/g, reaction temperature 50 ℃, reaction time 100min, and feeding amount ratio VC: CaCO3 = 1: 0.525. The average content of vitamin C and calcium generated under this reaction condition is 99.35%, and the yield reaches 86.91%.
2. product obtained by neutralizing ascorbic acid with calcium carbonate or calcium oxide.
identification test
10% the calcium test (IT-10) of the sample solution was positive, and the 2,6-dichlorophenol-indophenol test solution (TS-84) faded.
content analysis
accurately weigh the sample about 300mg, dissolve it in 50ml of water in a 250ml conical flask, immediately titrate it to light yellow with 0.1mol/L iodine solution and maintain it for more than 30s. 0.1mol/L iodine solution per mL is equivalent to calcium ascorbate (C12 H1tCaOl2?2H20)10.66mg.
Toxicity
ADI does not make special regulations (FAO/WHO,2001).
GRAS(FDA,& sect;182.3189,2000).
use limited
FAO/WHO(1984): soup, soup (cooked from meat, chicken, etc.), 1000 mg/kg (measured by ascorbic acid).
GB 2760-96: (g/kg) crisp cakes, instant noodles, 0.2; Soup, meat products, 1.0 (measured by ascorbic acid in oil).
Last Update：2024-04-10 22:29:15
Calcium diascorbate - Nature
| Specific rotation | D20 95.6° (c = 2.4) |
| EPA chemical information | Calcium ascorbate anhydrous (5743-27-1) |
Last Update：2024-04-09 19:04:56
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Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
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